看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。. Y: K3 J3 c2 n! @# X& H9 s1 ~
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Currently available feasibility data for possible combination strategies. ; `. i* j4 l( Z7 H
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+ f& r) P5 I- t! @Combination Feasibility according to preliminary data
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9 B8 g' Z R5 sBevacizumab + sorafenib Yes, reduced dose
5 D; A& {8 r; }5 J' A9 oBevacizumab + sunitinib† No
$ q5 m6 j& t- x' O6 r* c! W9 ^Bevacizumab + temsirolimus Yes
: ~, ?- Y. u/ w. `/ SBevacizumab + everolimus Yes
* v: F" r6 r1 S7 j6 |8 i4 YSorafenib + sunitinib ?
+ B$ q$ G& s: I7 OSorafenib + temsirolimus Yes, reduced dose
7 f* X7 ^2 P2 uSorafenib + everolimus Yes, reduced dose
" K: m0 t- k5 F! R3 |Sunitinib + temsirolimus† No * P& S6 [. H/ x$ I) P" ~3 C7 l
Sunitinib + everolimus ? 5 O; l4 o" p# h) l
Temsirolimus + everolimus ? & U1 X3 Q- _ e A
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†Led to US FDA warning.
. x( Z, \9 v# G0 a2 i. [?: As yet unattempted combination.
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