脑部放疗，上午比下午敏感许多！- s2 X1 V# s% ?6 H& U1 v
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Cancer 2011 Jan 15;117(2):414-20. doi: 10.1002/cncr.25423. Epub 2010 Sep 9.' I: Q! O( C! O3 S
Gamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: is there a difference in outcome between morning and afternoon treatment?* z" n2 `/ t' |* Y( @* }
Rahn DA 3rd, Ray DK, Schlesinger DJ, Steiner L, Sheehan JP, O'Quigley JM, Rich T.
! v& r: F- G0 ~: ?. Z! n4 P+ p' gSourceDepartment of Radiation Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.
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Abstract
. i, z. h) {0 E M4 S+ J9 B0 o, mBACKGROUND: Circadian cell-cycle progression causes fluctuating radiosensitivity in many tissues, which could affect clinical outcomes. The purpose of this study was to determine whether outcomes of single-session gamma knife radiosurgery (GKRS) for metastatic nonsmall cell lung cancer (NSCLC) differ based on treatment time.. P8 a& n+ T& t! x
- ^8 }, s \, N' H- n9 W+ TMETHODS: Fifty-eight patients received GKRS between 10:00 am and 12:30 pm and 39 patients received GKRS between 12:30 pm and 3:00 pm. The mean peripheral dose was 18.6 Gy. The mean tumor size was 7.3 cm³. Magnetic resonance imaging was used to score local control at 3 months. Cause of death (COD) was categorized as central nervous system (CNS)-related or systemic.
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- y E% f. N' C$ rRESULTS: Demographic and disease characteristics of the 2 groups were similar. Local control at 3 months was achieved in 97% (35/36) of patients who underwent GKRS early in the day versus 67% (8/12) of patients who underwent GKRS later in the day (chi-square, P = .014). Early GKRS was associated with better survival (median 9.5 months) than late GKRS (median 5 months) (Kaplan-Meier log-rank test, P = .025). Factors contributing to better survival in a Cox regression model included early treatment time (P = .004) and recursive partition analysis class (P < .001). Cause of death in the early treatment group was CNS-related in 6% (3/47) of patients versus 24% (8/34) of patients in the late treatment group (chi-square test, P = .026).
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+ I) C( d2 O" ] vCONCLUSIONS: GKRS for metastatic NSCLC had better local control, better survival, and a lower rate of CNS-related cause of death when given earlier in the day versus later in the day. These retrospective data should encourage future study in brain radiosurgery and non-CNS stereotactic body radiotherapy series.
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乙状结肠癌肝肺转移
乙状结肠癌肝肺转移，现已经做了第一阶段的治疗，介入奥沙，加口服卡培滨，复方斑蝥胶
重启化疗后疼痛一直加重，是化疗无效
治疗经过如下：
Kras G12c 20.16%附带一个1.31%丰度的egfr21 PDL1阴性
靶向药的课题
依沃西用药后，该怎么办？
依沃西用药后，该怎么办？
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2020年12月1号，妈妈在确诊晚期肺癌4年零10月，经历了化疗、一代靶向易
初诊必看：肿瘤患者诊断时最关心的10
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治不治
有人说，给父母看病治病天经地义，这是个值得讨论的话题吗？
我
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显身卡
