平安! 发表于 2011-11-9 19:57 8 x, d1 [/ A2 u) S
Pazopanib (100 mg/kg/day free base equivalent)
) E) ]; G: f7 o& q9 K5 y6 L 这是个已经在美国上市的老药了,能下载到正式药物使用说明书英文版。
! ~) y; J) X4 a3 h搜索了一下,原料一大堆。
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对不起!100mg/kg是用于移植瘤的,我弄错了。' K2 I3 P1 {7 ^! x& a% V- P
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以下是正版说明书的推荐用量。1 M( M2 D' W! \! f
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--------------------- DOSAGE AND ADMINISTRATION ----------------
3 @; `, F i* C1 r( H4 r, H4 Z* |* 800 mg orally once daily without food (at least 1 hour before or 2 hours after a meal). (2.1) 9 P, L1 N6 }5 e
* Baseline moderate hepatic impairment – 200 mg orally once daily. Not recommended in patients with severe hepatic impairment. (2.2) ! ~8 W! e8 S. {9 U- s" A( d
---------------------DOSAGE FORMS AND STRENGTHS --------------" x0 a" a& T0 ^% X* E2 k
200 mg tablets. (3) * d+ A, `, `5 w+ _$ p
-------------------------------CONTRAINDICATIONS------------------------ |