发给老马备查:0 W- J1 T! D8 _% i& `; R) \, e
滴水察海(69304838) 15:23:233 d9 K' C2 H5 H% t/ ?
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
1 `, h: S) M* p6 r' N吉非替尼和S-1连用的依据
2 H/ R4 Q9 I" G" R% I' U# H9 VGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
. u- y+ M; U l4 L% b; ~/ s& i" l0 g是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达* ~: }, w& s: q
这样是不是推理出,耐药后,可以用S-1和培美了?, f# M* p7 s' x( t: N8 B, H+ t% m
结论:
, r! h- B1 k6 t( J* d Z" ]' ~: ]" v% o如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |