发给老马备查:4 ^ E/ Z3 B/ o
滴水察海(69304838) 15:23:23 ( B, U1 T3 {7 Y3 x, r老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱 4 h ]" c6 X- j8 o吉非替尼和S-1连用的依据7 s1 d, c: n# r; ^% Q3 s. ^$ i
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro. O, {8 {4 @. K9 w0 y* M5 s' J是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达 , n7 K4 z8 j0 Q4 h. {+ ^: V这样是不是推理出,耐药后,可以用S-1和培美了?( f, X9 k0 s" _/ _6 m0 u2 V
结论: ( u& r& [2 G _0 y5 T' I& b# S如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。